2014 ASHS Annual Conference

Fraunhofer USA, Inc. Center for Molecular Biotechnology (FhCMB) has pioneered a transient plant-based bio-pharmaceutical platform to produce vaccines and therapeutics quickly and cost-effectively. Using this platform, plants are grown in a controlled environment using a hydroponic system. The plants are vacuum infiltrated with a recombinant Agrobacteria carrying a plant viral based-launch vector and returned to a controlled environment for the target protein to be produced in infiltrated plant tissue. When target protein levels peak in leaf tissue, the plants are harvested and homogenized, extract is clarified and the target protein is purified. There are multiple opportunities in this system for LED’s to be applied to optimize biomass accumulation and the production of target proteins. There is potential to develop specific lighting recipes to optimize plant growth and target protein production.