ASHS 2015 Annual Conference
Structure, Function and IgE Epitopes of the Peanut Panallergen Ara h 8
Structure, Function and IgE Epitopes of the Peanut Panallergen Ara h 8
Friday, August 7, 2015: 8:15 AM
Bayside B (Sheraton Hotel New Orleans)
Bet v 1 from birch pollen is a common sensitizing agent and Oral Allergy Syndrome (OAS) results when patients consume certain fruits, vegetables, tree nuts and peanuts. Here, we report the 3-dimensional structure of Ara h 8, the Bet v 1 homolog from peanut. The overall fold is very similar to that of Bet v 1, Api g 1 (celery), Gly m 4 (soy) and Pru av 1 (cherry). Ara h 8 binds the isoflavones quercetin and apigenin, as well as resveratrol avidly. Using micro-chip technology we have mapped the important linear epitopes for IgE binding.
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