2018 ASHS Annual Conference

Chronic pain caused by injuries or disease impedes performance, and also leads to anxiety, depression and disability. non-opiate, antiinflammatory painkillers need to be developed. Phenotypes of high polyphenol plants in the Brassicaceae have been developed from abiotic stimuli experiments. Vegetatively propagated lines of three plant species used in medicinal or nutraceutical treatments were screened for polyphenol production in specific cell types. Analytical chemistry has permitted identification of polyphenol and other constituents in vegetative material. Polyphenols administered to mice reduce inflammatory pain responses. Analysis of chemical stability indicate specific solvents and concentrations affect shelf life and mode of administration. Analysis of seeds and seedlings indicate selection criteria based on polyphenols may speed production of useful pharmaceuticals.